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Patent 2860824 Summary

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(12) Patent: (11) CA 2860824
(54) English Title: USE OF PROTHIOCONAZOLE FOR CONTROLLING SCLEROTINIA AND/OR INCREASING YIELD IN CANOLA HYBRID PLANTS
(54) French Title: UTILISATION DU PROTHIOCONAZOLE POUR LE CONTROLE DE LA SCLEROTINIA ET/OUL'AUGMENTATION DU RENDEMENT DES PLANTS HYBRIDES DE CANOLA
Status: Granted
Bibliographic Data
(51) International Patent Classification (IPC):
  • A01N 47/38 (2006.01)
  • A01N 43/36 (2006.01)
  • A01N 43/40 (2006.01)
  • A01N 43/54 (2006.01)
  • A01N 43/56 (2006.01)
  • A01N 43/653 (2006.01)
  • A01P 3/00 (2006.01)
(72) Inventors :
  • EADIE, ALLAN (Canada)
(73) Owners :
  • BAYER CROPSCIENCE INC. (Canada)
(71) Applicants :
  • BAYER CROPSCIENCE INC. (Canada)
(74) Agent: SMART & BIGGAR LP
(74) Associate agent:
(45) Issued: 2022-01-11
(22) Filed Date: 2014-08-28
(41) Open to Public Inspection: 2016-02-28
Examination requested: 2019-08-15
Availability of licence: N/A
(25) Language of filing: English

Patent Cooperation Treaty (PCT): No

(30) Application Priority Data: None

Abstracts

English Abstract

The present invention relates to a new use of certain fungicides, in particular prothioconazole for controlling microbial diseases and/or increasing yield of selected canola hybrids as well as a new method of treating Canola hybrid plant or plant parts with a composition comprising certain fungicides, in particular for controlling microbial diseases and/or increasing yield of the plants.


French Abstract

La présente invention concerne un nouveau mode dutilisation de certains fongicides, plus particulièrement le prothioconazole, servant à contrôler les maladies microbiennes et/ou à améliorer le rendement des variétés de canola hybride sélectionnées. Elle porte également sur une nouvelle méthode de traitement des plantes de canola hybrides, ou de ses parties, au moyen dune composition constituée de certains fongicides, soit les fongicides servant à contrôler les maladies microbiennes et/ou à améliorer le rendement des plantes en particulier.
Claims

Note: Claims are shown in the official language in which they were submitted.


81781694
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CLAIMS:
1. Use of prothioconazole for controlling Sclerotinia sclerotiorum and/or
Sclerotinia minor to
increase yield of an InVigorTM L1605 Canola hybrid to at least 102% relative
to the yield of an
untreated InVigorTm L1605 Canola hybrid.
2. Use according to claim 1, wherein the use comprises increasing the yield of
the InVigorTM
L1605 Canola hybrid to at least 105% relative to the yield of an untreated
InVigorn4 L1605
Canola hybrid.
3. Use according to claim 1 or 2, wherein the use comprises controlling
Sclerotinia sclerotiorum
and/or Sclerotinia minor in the Canola hybrid plants by at least 40 % compared
to the untreated
InVigorTm L1605 Canola hybrid.
4. Use according to any one of claims 1 to 3, wherein the prothioconazole is
for application to
the Canola hybrid plants at a growth stage defined by BBCH codes from BBCH 60
to BBCH
65.
5. Method of controlling Sclerotinia sclerotiorum and/or Sclerotinia minor to
increase yield of
an InVigorTm L1605 Canola hybrid to at least 102% relative to the yield of an
untreated
InVigorTm L1605 Canola hybrid, the method comprising applying prothioconazole
to the
InVigorTm L1605 Canola hybrid plants or plant parts thereof.
6. Method according to claim 5, wherein the applying of the prothioconazole is
done at a growth
stage defined by BBCH codes from BBCH 60 to BBCH 65.
7. Method according to claim 5 or 6, wherein the applying of the
prothioconazole is done at an
application rate from 10 g/ha to 800 g/ha.
8. Method according to claim 6 or 7, wherein the applying of the
prothioconazole is done at an
application rate from 100 g/ha to 600 g/ha.
9. Method according to claim 6 or 7, wherein the applying of the
prothioconazole is done at an
application rate from 130 g/ha to 550 g/ha.
Date Recue/Date Received 2021-06-25

Description

Note: Descriptions are shown in the official language in which they were submitted.


81781694
USE OF OF PROTHIOCONAZOLE FOR CONTROLLING SCLEROTINIA AND/OR INCREASING
YIELD IN CANOLA HYBRID PLANTS
Field of the Invention
The present invention relates to the use of certain fungicides, in particuiar
prothioconazole for controlling certain
microbial diseases and/or increasing yield of selected canola hybrids, to
methods applying these fungicides alone
or in combinations to Canola hybrids.
Background of the Invention
Canola belonging to the family of Brassicracreae is characterized by a low
level of glucosinolates and erucic acid
in the canola seeds. Canola is infected by a variety of different microbial
diseases. The most important microbial
diseases are black leg caused by Leptosphaeria maculans, downy mildew caused
by Peronospora parasitic a, root
rot caused by Rhizoctonia solani, Fusariurn and Pythium species, sclerotinia
stem rot (white mould) caused by
Sclerotinia scierotiorum and Sclerotinia minor, seedling disease complex
caused by Rhizoctonia
Fusarium and Pythium species, white leaf and gray stem caused by
Pseudocercosporella capsellae, White rust
(staghead) caused by Albugo candida, clubroot caused by Plasmodiophora
brassicae, Alternaria black spot
caused by Alternaria brassicare, Alternaria alterriata and Alternaria raphani.
Of these diseases Sclerotinia is one of the most important diseases as it can
cause significant losses in yield and
quality of the canola seeds. An overview about the disease is given in WO-A
2006/1357171, The apothecia
which originate from the germinated sclerotia in summer release ascospores
which are distributed by wind over
significant distances. In order to successfully infect the plant the spores
need moist soil conditions and
temperatures around 20 degrees Celsius. Leaves and stems are not directly
infected by the spores but rather by
flowers or petals, in particular older petals. Disease development starts
several weeks after flowering. At that
stage stems, leaves and pods can be infected so that no or less seeds are
produced or the infected plants lodge or
shatter at harvest. A new generation of sclerotia will develop which will be
responsible for the infection in th6
next season
The severity of the disease in each season is strongly influenced by the
climatic conditions being present at the
time of infection as the fungus needs temperatures around 20 degree ceIsius
and more than 80 'A humidity in the
crop canopy.
As all Canadian canola genotypes are in general susceptible to Sclerotinia in
recent years three different
approaches have been used to improve Sclerotinia control in Canola being
control by chemical fungicides,
breeding for disease resistance or tolerance and agronomic methods.
The fungicides azoxystrobin, bescalid, eyprodinil, fludioxonfl, iprodione,
penthiopyracl, picoxystrobin,
prothioconazole are already described for use against Sclerotinia sclerotiorum
and/or Sclerotinia minor in Canola
Date Recue/Date Received 2021-06-25

81781694
- 2 -
and are also available as commercial products for treatment of fungal disease
in Canola
(Astound'TM, Acapela'TM, Lance', RovralTm, ProlineTm, QuadrisTm, VertisanTm)
(see Crop
Protection Guide published by the Alberta Agriculture and Rural Development,
2014).
Although significant efforts have been made to breed for Sclerotinia resistant
or tolerant Canola
varieties the success so far has been limited. There are varieties that are
less susceptible due to
morphological features like lighter canopies (WO-A 2006/1357171).
Therefore, the objective of the present invention was to provide improved
solutions for
controlling Sclerotinia sclerotiorum and/or Sclerotinia minor and/or
increasing yield in Canola
hybrids selected from the group consisting of In VigorTm L252, L261, L160S and
L140P. A
further object of the present invention was a method of applying the
fungicides simultaneously
or sequentially on these hybrids.
Summary of the Invention
Surprisingly it has been found that this object is achieved by the use of
fungicides selected from
the group consisting of azoxystrobin, boscalid, cyprodinil, fludioxonil,
iprodione, penthiopyrad,
picoxystrobin, prothioconazole and mixtures thereof for controlling
Sclerotinia sclerotiorum
and/or Sclerotinia minor and/or increasing yield in Canola hybrids selected
from the group
consisting of In Vigor L252, L261, L160S and L140P.
A further object of the present invention was a method of applying the
fungicides
simultaneously or sequentially on these hybrids.
In one aspect, the present invention provides use of prothioconazole for
controlling Sclerotinia
sclerotiorum and/or Sclerotinia minor to increase yield of an InVigorTm L160S
Canola hybrid
to at least 102% relative to the yield of an untreated InVigorTm L1605 Canola
hybrid.
In another aspect, the present invention provides method of controlling
Sclerotinia sclerotiorum
and/or Sclerotinia minor to increase yield of an InVigorTm L1605 Canola hybrid
to at least
102% relative to the yield of an untreated InVigorTm L1605 Canola hybrid, the
method
Date Recue/Date Received 2021-06-25

81781694
- 2a -
comprising applying prothioconazole to the InVigoem L160S Canola hybrid plants
or plant
parts thereof.
General Definitions
Azoxystrobin (CAS Registry No. 131860-33-8), having the chemical name (E)-
methy12-[[6-(2-
cyanophenoxy)-4-pyrimidinyl]oxy]-alpha.-(methoxymethylene)benzeneacetate and
its
manufacturing process is described in EP-A 382 375 and is described in formula
(I)
0
ii
0
illN N
01).
Date Recue/Date Received 2021-06-25

CA 02860824 2014-08-28
BCS 14-3033 Ca Prio
-3-
=
Boscalid (CAS Registry No. 188425-85-6), having the chemical name 2-chloro-N-
(4'-chloro[1,1'-bipheny1]-2-yI)-
3-pyridinecarboxamide and its manufacturing process is described in EP-A 545
099 and is described in the
formula (II)
CI
N CI
0
(II)
Cyprodinil (CAS Registry No. 121552-61-2), having the chemical name 4-
cyclopropy1-6-methyl-N-pheny1-2-
pyrirnidinamine and its manufacturing process is described in EP-A 310 550 and
is described in the formula
(111)
NH
N N
(III).
Fludioxonil (CAS Registry No. 131341-86-1), having the chemical name 4-(2,2-
difluoro-1,3-benzodioxo1-4-y1)-
1H-pyrrole-3-carbonitrile and its manufacturing process is described in EP-A
206 999 and is described in the
formula (IV)

CA 02860824 2014-08-28
BCS 14-3033 CA-Prio
_4_
N
0><F
0
(IV)
Iprodione (CAS Registry No. 36734-19-7), having the chemical name 3-(3,5-
dichloropheny1)-N-(1-methylethyl)-
2,4-dioxo-1 -imidazolidincarboxamide and its manufacturing process is
described in DE-A 2 149 923 and is
described in the formula (V)
NH
C:INNZLO
CI CI (v).
Penthiopyrad (CAS Registry No. 183675-82-3), having the chemical name (RS)-N42-
(1,3-Dimethylbuty1)-
thiophen-3-yd1 -methyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxamide and its
manufacturing process is
described in EP-A 737 682 and is described in the formula (VI)

CA 02860824 2014-08-28
BCS 14-3033 Ca Prio
-5-
F F
(VI)
Picoxystrobin (CAS Registry No. 117428-22-5), having the chemical name
(a1pha.E)-methylalpha-
(methoxymethylene)-2-[[[6-(trifluoromethyl)-2-pyridinyl]oxy]methyl]-
benzeneacetate and its manufacturing
.. process is described in EP-A 278 595 and is described in the formula (VII)
0 (VII).
Prothioconazole (CAS Registry No. 178928-70-6), having the chemical name 242-
(1-chlorocyclopropy1)-3-(2-
chloropheny1)-2-hydroxypropyli-1,2-dihydro-3H-1,2,4-triazole-3-thione and its
manufacturing process is
described in WO-A 96/16048.
Prothioconazole can be present in the õthionoõ form of the formula (VIII)

81781694
-6-
CI ?H
41 CH2 Ti ____________________________ CI
CH
I2
NS
II 1
or in the tautomeric õmercaptoõ form of the formula
CI
It CHC--7 ____________________________ CI
CH
I 2 (Villa)
Nil IT
By using the common name prothioconazole both tautomeric forms are covered.
The Canola Hybrids InVigor L252, L261, LI6OS and L140P are registered
varieties under the Canadian Seeds
Act with the Canadian Food Inspection Agency as Canola, Brassica napus L.,
Spring hybrid under the respective
names L252, L261, L160S and L140P. The list of registered variety is published
online on the homepage of the
Canadian Food Inspection Agency under the subsection "Registered Varieties and
Notifications". They are
commercially available at the time of filing.
In the context of the present invention, "control of Sclerotinia sclerotiorum
and/or Sclerotinia minor" means a
reduction in infestation by Sclerotinia scierotiorum and/or Sclerotinia minor,
compared with the untreated plant
or plant part as defined below measured as Disease Severity Index (DSI),
preferably a reduction by 40 %,
compared with the untreated plant, more preferably a reduction by 50 %
compared with the untreated plant; even
more preferably a reduction by 80 % compared with the untreated plant; most
preferably the infection by
Sclerotinia sclerotiorum and/or Sclerotinia minor is entirely suppressed (over
90 %). The control may be curative,
Date Recue/Date Received 2021-06-25

81781694
-7-
i.e. for treatment of already infected plants, or protective, for protection
of plants which have not yet been
infected.
In the context of the present invention, "increasing yield" means an inCreased
amount in the harvested seeds per
area unit, compared with the untreated plant or plant part as defined below
measured as yield in relative increase
whereas the yield of the untreated control is defined to be 100 %. Preferably
an increase to 102 %, compared
with the untreated plant (100 %), more preferably an increase to 105 %
compared with the untreated plant (100
even more preferably, an increase to 110 % compared with the untreated plant
(100 %), most preferably, an
increase to 125 % compared with the untreated plant (100 %).
Detailed Description
In one embodiment of the present invention azoxystrobin is used for
controlling Sclerotinia sclerotiorum and/or
Sclerotinia minor and/or increasing yield in Canola hybrids selected from the
group consisting of InVigor L252,
L261, L160S and L140P.
In one embodiment of the present invention azoxystrobin is used for
controlling Sclerotinia sderotiorum and/or
Sclerotinia minor and/or increasing yield in Canola hybrid L252.
In one embodiment of the present invention azoxystrobin is used for
controlling Sclerotinia sclerotiorum and/or
Sclerotinia minor and/or increasing yield in Canola hybrid L261.
In one embodiment of the present invention azoxystrobin is used for
controlling Sclerotinia sclerotiortan and/or
Sderotinia minor and/or increasing yield in Canola hybrid Ll 60S.
In one embodiment of the present invention azoxystrobin is used for
controlling Sclerotinia sclerotiorum and/or
Sclerotinia minor and/or increasing yield in Canola hybrid L140P.
In one embodiment of the present invention azoxystrobin is used for
controlling Sclerotinia sclerotiorum and/or
Sclerotinia minor in Canola hybrid L252.
In one embodiment of the present invention azoxystrobin is used for
controlling Sclerotinia sclerotiorum and/or
Sclerotinia minor in Canola hybrid L261.
In one embodiment of the present invention azoxystrobin is used for
controlling Sclerotinia sclerotiorum and/or
Sclerotinia minor in Canola hybrid Li 60S.
In one embodiment of the present invention azoxystrobin is used for
controlling Sclerotinia sclerotiorum and/or
Sclerotinia minor in Canola hybrid L140P.
Date Recue/Date Received 2021-06-25

81781694
-8-
In one embodiment of the present invention azoxystrobin is used for increasing
yield in Canola hybrid L252.
In one embodiment of the present invention azoxystrobin is used for increasing
yield in Canola hybrid L261.
In one embodiment of the present invention azoxystrobin is used for increasing
yield in Canola hybrid Li 60S.
In one embodiment of the present invention azoxystrobin is used for increasing
yield in Canola hybrid L140P.
.. In one embodiment of the present invention boscalid is used for controlling
Sclerotinia sclerotioruin and/or
Sclerotinio minor and/or increasing yield in Canola hybrids selected from the
group consisting of InVigor L252,
L261, L160S and L140P.
In one embodiment of the present invention boscalid is used for controlling
Sclerotinia sclerotiorum and/or
Sclerotinio minor and/or increasing yield in Canola hybrid L252.
In one embodiment of the present invention boscalid is used for controlling
Sclerotinio sclerotiorum and/or
Selerotinio minor and/or increasing yield in Canola hybrid L261.
In one embodiment of the present invention boscalid is used for controlling
Selerotinia sclerotiortim and/or
Selerotinio minor and/or increasing yield in Canola hybrid Li 60S.
In one embodiment of the present invention boscalid is used for controlling
Sclerotinia scierotiorum and/or
.. Scierotinia minor and/or increasing yield in Canola hybrid L140P.
In one embodiment of the present invention boscalid is used for controlling
Sclerotinia sclerotiorum and/or
Sclerotinia minor in Canola hybrid L252.
In one embodiment of the present invention boscalid is used for controlling
Selerotinio sclerotiorum and/or
Sclerotinia minor in Canola hybrid L26 I.
In one embodiment of the present invention boscalid is used for controlling
Sclerotinia sclerotiorum and/or
Selerotinio minor in Canola hybrid L160S.
In one embodiment of the present invention boscalid is used for containing
Sclerotinio sclerotiorum and/or
Selerotinia minor in Canola hybrid L140P.
In one embodiment of the present invention boscalid is used for increasing
yield in Canola hybrid L252.
In one embodiment of the present invention boscalid is used for increasing
yield in Canola hybrid L261.
In one embodiment of the present invention boscalid is used for increasing
yield in Canola hybrid L160S.
Date Recue/Date Received 2021-06-25

81781694
-9-
In one embodiment of the present invention boscalid is used for increasing
yield in Canola hybrid 1,140P.
In one embodiment of the present invention cyprodinil is used for controlling
Sclerotinio sclerotiorum and/or
Sclerotinio minor and/or increasing yield in Canola hybrids selected from the
group consisting of InVigor L252,
L261, L160S and L140P.
In one embodiment of the present invention cyprodinil is used for controlling
Sclerotinia scierotiorum and/or
Sclerotinio minor and/or increasing yield in Canola hybrid L252.
In one embodiment of the present invention cyprodinil is used for controlling
Sclerotinio sclerotiorum and/or
Sclerotinia minor and/or increasing yield in Canola hybrid L261.
In one embodiment of the present invention cyprodinil is used for controlling
Sclerotinio scleratiorum and/or
Sclerotinio minor and/or increasing yield in Canola hybrid L160S.
In one embodiment of the present invention cyprodinil is used for controlling
Sclerotinio sclerotiorum and/or
Sclerotinia minor and/or increasing yield in Canola hybrid L140P.
In one embodiment of the present invention cyprodinil is used for controlling
Sclerotinia sclerotiorum and/or
Sclerotinia minor in Canola hybrid L252.
In one embodiment of the present invention cyprodinil is used for controlling
Sclerotinia sclerotiorum and/or
Sclerotinto minor in Canola hybrid L261.
In one embodiment of the present invention cyprodinil is used for controlling
Scleratinia sclerotiorum and/or
Scleratinia minor in Canola hybrid LI 60S.
In one embodiment of the present invention cyprodinil is used for controlling
Sclerotinio sclerotiorum and/or
Sclerotinia minor in Canola hybrid L140P.
In one embodiment of the present invention cyprodinil is used for increasing
yield in Canola hybrid L252.
In one embodiment of the present invention cyprodinil is used for increasing
yield in Canola hybrid L261.
In one embodiment of the present invention cyprodinil is used for increasing
yield in Canola hybrid L1605.
In one embodiment of the present invention cyprodinil is used for increasing
yield in Canola hybrid L140P.
In one embodiment of the present invention fludioxonil is used for controlling
Sclerotinio sclerotiorum and/or
Sclerotinia minor and/or increasing yield in Canola hybrids selected from the
group consisting of In Vigor L252,
L261, L1605 and L140P.
Date Recue/Date Received 2021-06-25

81781694
-10-
In one embodiment of the present invention fludioxonil is used for
.controlling Sclerotinia sclerotiorum and/or
Sclerotinia minor and/or increasing yield in Canola hybrid L252.
In one embodiment of the present invention fludioxonil is used for controlling
Sclerotinia sclerotiorum and/or
Sclerotinia minor and/or increasing yield in Canola hybrid L261.
In one embodiment of the present invention fludioxonil is used for controlling
Sclerotinia sclerotiorum and/or
Sclerotinia minor and/or increasing yield in Canola hybrid L1605.
In one embodiment of the present invention fludioxonil is used for controlling
Sclerotinia sclerotiorum and/or
Sclerotinia minor and/or increasing yield in Canola hybrid LI4OP.
In one embodiment of the present invention fludioxonil is used for controlling
Sclerotinia sclerotiorum and/or
.. Sclerotinia minor in Canola hybrid L252.
In one embodiment of the present invention fludioxonil is used for controlling
Sclerotinia sclerotiorum and/or
Sclerotinia minor in Canola hybrid L261.
In one embodiment of the present invention fludioxonil is used for controlling
Sclerotinia sclerotiorum and/or
Sclerotinia minor in Canola hybrid L160S.
In one embodiment of the present invention fludioxonil is used for controlling
Sclerotinia sclerotiorum and/or
Sclerotinia minor in Canola hybrid L140P.
In one embodiment of the present invention fludioxonil is used for increasing
yield in Canola hybrid L252.
In one embodiment of the present invention fludioxonil is used for increasing
yield in Canola hybrid L261.
In one embodiment of the present invention fludioxonil is used for increasing
yield in Canola hybrid L1605.
In one embodiment of the present invention fludioxonil is used for increasing
yield in Canola hybrid 1,140P.
In one embodiment of the present invention iprodione is used for controlling
Sclerotinia sclerotiorum and/or
Sclerotinia minor and/or increasing yield in Canola hybrids selected from the
group consisting of InVigor L252,
L261, L1605 and 1,140P.
In one embodiment of the present invention iprodione is used for controlling
Scierotinia sclerotiorum and/or
Sclerotinia minor and/or increasing yield in Canola hybrid L252.
In one embodiment of the present invention iprodione is used for controlling
Sclerotinia sclerotiorum and/or
Sclerotinia minor and/or increasing yield in Canola hybrid L261.
Date Recue/Date Received 2021-06-25

8 1 7 8 1 6 94
-11-
In one embodiment of the present invention iprodione is used for controlling
Selerotinia selerotiortim and/or
Sclerotinia minor and/or increasing yield in Canola hybrid L160S.
In one embodiment of the present invention iprodione is used for controlling
Selerotinia selerotiortim and/or
Sclerotinia minor and/or increasing yield in Canola hybrid L140P.
In one embodiment of the present invention iprodione is used for controlling
Sclerotinio sclerotiortim and/or
Sclerotinia minor in Canola hybrid L252.
In one embodiment of the present invention iprodione is used for controlling
Selerotinia sclerotiorum and/or
Sclerotinia minor in Canola hybrid L261.
In one embodiment of the present invention iprodione is used for controlling
Sclerotinia sclerotiorum and/or
Sclerotinia minor in Canola hybrid L160S.
In one embodiment of the present invention iprodione is used for controlling
Selerotinia selerotiortim and/or
Selerotinia minor in Canola. hybrid L140P.
In one embodiment of the present invention iprodione is used for increasing
yield in Canola hybrid L252.
In one embodiment of the present invention iprodione is used for increasing
yield in Canola hybrid L261.
In one embodiment of the present invention iprodione is used for increasing
yield in Canola hybrid L1605.
In one embodiment of the present invention iprodione is used for increasing
yield in Canola hybrid L140P.
In one embodiment of the present invention penthiopyrad is used for
controlling Selerotinia selerotiorzun and/or
Sclerotinia minor and/or increasing yield in Canola hybrids selected from the
group consisting of InVigor L252,
L261, L160S and L140P.
In one embodiment of the present invention penthiopyrad is used for
controlling Sclerotinia sclerotiorum and/or
Selerotinio minor and/or increasing yield in Canola hybrid L252.
In one embodiment of the present invention penthiopyrad is used for
controlling Sclerotinia selerotiorum and/or
Sclerotinio minor and/or increasing yield in Canola hybrid L261.
In one embodiment of the present invention penthiopyrad is used for
controlling Selerotinia selerotiortiin and/or
Selerotinia minor and/or increasing yield in Canola hybrid L1605.
In one embodiment of the present invention penthiopyrad is used .for
controlling Sclerotinia sclerotiorum and/or
Scierotinio minor and/or increasing yield in Canola hybrid L140P.
Date Recue/Date Received 2021-06-25

81781694
-12-
In one embodiment of the present invention penthiopyrad is used for
controlling Sclerotinia sclerotiorum and/or
Sclerotinia minor in Canola hybrid L252.
In one embodiment of the present invention penthiopyrad is used for
controlling Sclerotinia sclerotiorum and/or
Sclerotinia minor in Canola hybrid L261.
.. In one embodiment of the present invention penthiopyrad is used for
controlling Sclerotinia sclerotiorum and/or
Sclerotinia minor in Canola hybrid L160S.
In one embodiment of the present invention penthiopyrad is used for
controlling Sclerotinia sclerotiorum and/or
Sclerotinia minor in Canola hybrid L140P.
In one embodiment of the present invention penthiopyrad is used for increasing
yield in Canola hybrid L252.
.. In one embodiment of the present invention penthiopyrad is used for
increasing yield in Canola hybrid L261.
In one embodiment of the present invention penthiopyrad is used for increasing
yield in Canola hybrid L160S.
In one embodiment of the present invention penthiopyrad is used for increasing
yield in Canola hybrid L140P.
In one embodiment of the present invention prothioconazole is used for
controlling Sclerotinia sclerotiorum
and/or Sclerotinia minor and/or increasing yield in Canola hybrids selected
from the group consisting of InVigor
L252, L261, LI6OS and L140P.
In one embodiment of the present invention prothioconazole is used for
controlling Sclerotinia sclerotiortim
and/or Sclerotinia minor and/or increasing yield in Canola hybrid L252.
In one embodiment of the present invention prothioconazole is used for
controlling Sclerotinia sclerotiorum
and/or Sclerotinia minor and/or increasing yield in Canola hybrid L261.
.. In one embodiment of the present invention prothioconazole is used for
controlling Sclerotinia sclerotiorum
and/or Sclerotinia minor and/or increasing yield in Canola hybrid Li 60S.
In one embodiment of the present invention prothioconazole is used for
controlling Sclerotinia sclerotiornm
and/or Sclerotinia minor and/or increasing yield in Canola hybrid L140P.
In one embodiment of the present invention prothioconazole is used for
controlling Sclerotinia sclerotiorum
.. and/or Sclerotinia minor in Canola hybrid L252.
In one embodiment of the present invention prothioconazole is used for
controlling Sclerotinia sclerotiorum
and/or Sclerotinia minor in Canola hybrid L261.
Date Recue/Date Received 2021-06-25

8 1 7 8 1 6 94
-13-
In one embodiment of the present invention prothioconazole is used for
controlling Scierotinia sclerotiorum
and/or Scierotinia minor in Canola hybrid L160S.
In one embodiment of the present invention prothioconazole is used for
controlling Scierotinia sclerotiorum
and/or Scierotinia minor in Canola hybrid L140P.
In one embodiment of the present invention prothioconazole is used for
increasing yield in Canola hybrid L252.
In one embodiment of the present invention prothioconazole is used for
increasing yield in Canola hybrid L261.
In one embodiment of the present invention prothioconazole is used for
increasing yield in Canola hybrid L160S.
In one embodiment of the present invention prothioconazole is used for
increasing yield in Canola hybrid L 140P.
In one embodiment of the present invention picoxystrobin is used for
controlling Scierotinia sclerotiorum and/or
Scierotinia minor and/or increasing yield in Canola hybrids selected from the
group consisting of InVigor L252,
L261, L160S and L140P.
In one embodiment of the present invention picoxystrobinis used for
controlling Scierotinia sclerotiorum and/or
Scierotinia minor and/or increasing yield in Canola hybrid L252.
In one embodiment of the present invention picoxystrobin is used for
controlling Scierotinia sclerotiorum and/or
Scierotinia minor and/or increasing yield in Canola hybrid L261.
In one embodiment of the present invention picoxystrobin is used for
controlling Scierotinia sclerotiorum and/or
Scierotinia minor and/or increasing yield in Canola hybrid L160S.
In one embodiment of the present invention picoxystrobin is used for
controlling Scierotinia sclerotiorum and/or
Scierotinia minor and/or increasing yield in Canola hybrid L140P.
In one embodiment of the present invention picoxystrobin is used for
controlling Scierotinia sclerotiorum and/or
Scierotinia minor in Canola hybrid L252.
In one embodiment of the present invention picoxystrobin is used for
controlling Scierotinia sclerotiorum and/or
Scierotinia minor in Canola hybrid L261.
In one embodiment of the present invention picoxystrobin is used for
controlling Scierotinia sclerotiorum and/or
Scierotinia minor in Canola hybrid L160S.
In one embodiment of the present invention picoxystrobin is used for
controlling Scierotinia sclerotiorum and/or
Scierotinia minor in Canola hybrid L140P.
Date Recue/Date Received 2021-06-25

81781694
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In one embodiment of the present invention picoxystrobin is used for
increasing yield in Canola hybrid L252.
In one embodiment of the present invention picoxystrobin is used for
increasing yield in Canola hybrid L261.
In one embodiment of the present invention picoxystrobin is used for
increasing yield in Canola hybrid L160S.
In one embodiment of the present invention picoxystrobin is used for
increasing yield in Canola hybrid L140P.
The active ingredients selected from the group consisting of azoxystrobin,
boscalid, cyprodinil, fludioxonil,
iprociione, penthiopyrad, picoxystrobin, prothioconazole are preferably used
in a weight ratio of 1:0.1 to 1:10,
more preferably in a weight ratio of 1:0.5 to 1:5. By using fludioxonil as
further agrochemically active
compound, the active ingredients cyprodinil and fludioxonil are preferably
used in a weight ratio of 1:0.1 to 1:10,
more preferably in a weight ratio of 1:0.5 to 1:2, most preferably in a weight
ratio of 1:0.5 to 1:1.5.
The present invention further relates to the above mentioned use of
prothioconazole, wherein the Brassicaceae
plant, in particular the oilseed rape plant is a transgenic plant.
Genetically modified organisms are for example plants or seeds. Genetically
modified plants are plants whose
genome has, stably integrated, a certain heterologous gene coding for a
certain protein. Here, "heterologous
gene" is meant to be taiderstood as a gene which confers novel agronomical
properties on the transformed plant,
or a gene which improves the agronomical quality of the modified plant.
As already mentioned above, it is possible to treat all plants and their parts
according to the invention. In a
preferred embodiment, wild plant species and plant cultivars, or those
obtained by conventional biological
breeding methods, such as crossing or protoplast fusion, and parts thereof,
are treated. In a further preferred
embodiment, trunsgenic plants und plant eultivars obtained by genetic;
engineering methods, if appropriate in
combination with conventional methods (genetically modified organisms), and
parts thereof are treated. The
terms "parts", "parts of plants" and "plant parts" have been explained above.
Particularly preferably, plants of the
plant cultivars which are in each case commercially available or in use are
treated according to the invention.
Examples of cytoplasmic male sterility (CMS) were for instance described in
Brass/ca species (WO 92/05251,
WO 95/09910, WO 98/27806, WO 05/002324, WO 06/021972 and US 6,229,072).
However, genetic
determinants for male sterility can also be located in the nuclear genome.
Male sterile plants can also be obtained
by plant biotechnology methods such as genetic engineering. A particularly
useful means of obtaining male-
sterile plants is described in WO 89/10396 in which, for example, a
ribonuclease such as barnase is selectively
expressed in the tapetum cells in the stamens. Fertility can then be restored
by expression in the tapetum cells of a
ribonuclease inhibitor such as barstar (e.g. WO 91/02069).
Herbicide-resistant plants are for example glyphosate-tolerant plants, i.e.
plants made tolerant to the herbicide
glyphosate or salts thereof. Plants can be made tolerant to glyphosate through
different means. For example,
Date Recue/Date Received 2021-06-25

CA 02860824 2014-08-28
BCS 14-3033 Ca Prio
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glyphosate-tolerant plants can be obtained by transforming the plant with a
gene encoding the enzyme 5-enolpyruvyl-
shikimate-3-phosphate synthase (EPSPS). Examples of such EPSPS genes are the
AroA gene (mutant C'F7) of the
bacterium Salmonella typhimurium (Science 1983, 221, 370-371), the CP4 gene of
the bacterium Agrobacterium sp.
(Curr. Topics Plant Physiol. 1992, 7, 139-145), the genes encoding a Petunia
EPSPS (Science 1986, 233, 478-481), a
Tomato EPSPS Biol. Chem. 1988, 263, 4280-4289), or an Eleusine EPSPS (WO
01/66704). It can also be a
mutated EPSPS as described in for example EP 0837944, WO 00/66746, WO 00/66747
or WO 02/26995, WO
11/000498. Glyphosate-tolerant plants can also be obtained by expressing a
gene that encodes a glyphosate oxido-
reductase enzyme as described in US 5,776,760 and US 5,463,175. Glyphosate-
tolerant plants can also be obtained by
expressing a gene that encodes a glyphosate acetyl transferase enzyme as
described in for example WO 02/036782,
WO 03/092360, WO 05/012515 and WO 07/024782. Glyphosate-tolerant plants can
also be obtained by selecting
plants containing naturally-occurring mutations of the above-mentioned genes,
as described in for example WO
01/024615 or WO 03/013226. Plants expressing EPSPS genes that confer
glyphosate tolerance are described in e.g.
U.S. Patent Applications 11/517,991, 10/739,610, 12/139,408, 12/352,532,
11/312,866, 11/315,678, 12/421,292,
11/400,598, 11/651,752, 11/681,285, 11/605,824, 12/468,205, 11/760,570,
11/762,526, 11/769,327, 11/769,255,
11/943801 or 12/362,774. Plants comprising other genes that confer glyphosate
tolerance, such as decarboxylase
genes, are described in e.g. U.S. Patent Applications 11/588,811, 11/185,342,
12/364,724, 11/185,560 or 12/423,926.
Other herbicide resistant plants are for example plants that are made tolerant
to herbicides inhibiting the enzyme
glutamine synthase, such as bialaphos, phosphinothricin or glufosinate. Such
plants can be obtained by
expressing an enzyme detoxifying the herbicide or a mutant glutamine synthase
enzyme that is resistant to
inhibition, e.g. described in U.S. Patent Application 11/760,602. One such
efficient detoxifying enzyme is an
enzyme encoding a phosphinothricin acetyltransferase (such as the bar or pat
protein from Streptomyces species).
Plants expressing an exogenous phosphinothricin acetyltransferase are for
example described in U.S. Patents
5,561,236; 5,648,477; 5,646,024; 5,273,894; 5,637,489; 5,276,268; 5,739,082;
5,908,810 and 7,112,665.
Still further herbicide resistant plants are plants that are made tolerant to
acetolactate synthase (ALS) inhibitors. Known
ALS-inhibitors include, for example, sulfonylurea, imidazolinone,
triazolopyrimidines, pyrimidinyoxy(thio)benzoates,
and/or sulfonylaminocarbonyltriazolinone herbicides. Different mutations in
the ALS enzyme (also known as
acetohydroxyacid synthase, AFIAS) are known to confer tolerance to different
herbicides and groups of herbicides, as
described for example in Tranel and Wright (Weed Science 2002, 50, 700-712),
but also, in U.S. Patents 5,605,011,
5,378,824, 5,141,870, and 5,013,659. The production of sulfonylurea-tolerant
plants and imidazolinone-tolerant plants
is described in U.S. Patents 5,605,011; 5,013,659; 5,141,870; 5,767,361;
5,731,180; 5,304,732; 4,761,373; 5,331,107;
5,928,937; and 5,378,824; and WO 96/33270. Other imiciamlinone-tolerant plants
are also described in for example
WO 04/040012, WO 04/106529, WO 05/020673, WO 05/093093, WO 06/007373, WO
06/015376, WO 06/024351,
and WO 06/060634. Further sulfonylurea- and imidazolinone-tolerant plants are
also described in for example WO
07/024782, WO 2011/076345, WO 2012058223, WO 2012150335 and U.S. Patent
Application 61/288958. Of

81781694
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TM
particular interest are varieties of winter rapeseed being resistant against
ALS-inhibitors (tradename Clearfield,
Clierfield Vantiga).
Plants of the genus Brass/ca (that can be obtained by plant biotechnology
methods such as genetic engineering)
which may also be treated according to the invention are plants with altered
oil profile characteristics. Such
plants can be obtained by genetic transformation, or by selection of plants
contain a mutation imparting such
altered oil profile characteristics and include:
a) Plants, such as oilseed rape plants, producing oil having a high oleic
acid content as described e.g. in US
5,969,169, US 5,840,946 or US 6,323,392 or US 6,063,947
b) Plants such as oilseed rape plants, producing oil having a low linolenic
acid content as described in US
6,270,828, US 6,169,190, US 5,965,755 or WO 11/060946
c) Plant such as oilseed rape plants, producing oil having a low level of
saturated fatty acids as described e.g. in
US 5,434,283 or U.S. Patent Application 12/668303
d) Plants such as oilseed rape plants, producing oil having an alter
glucosinolate content as described in WO
2012075426.
Plants of the genus Brass/ca (that can be obtained by plant biotechnology
methods such as genetic engineering)
which may also be treated according to the invention are plants with altered
seed shattering characteristics. Such
plants can be obtained by genetic transformation, or by selection of plants
contain a mutation imparting such
altered seed shattering characteristics and include plants such as oilseed
rape plants with delayed or reduced seed
shattering as described in WO 2009/068313 and WO 2010/006732, WO 2012090499.
Varieties of winter rapeseed being resistant against ALS-inhibitors are e.g.
such varieties available under
tradename Clearfield, Clierfield Vantiga.
Particularly useful transgenic plants which may be treated according to the
invention are plants containing
transformation events, or a combination of transformation events, and that are
listed for example in the databases
for various national or regional regulatory agencies Event M0N88302 (oilseed
rape, herbicide tolerance,
deposited as PTA-10955, described in WO 2011/153186), Event MS11 (oilseed
rape, pollination control -
herbicide tolerance, deposited as ATCC PTA-850 or PTA-2485, described in WO
01/031042); Event MS8
(oilseed rape, pollination control - herbicide tolerance, deposited as ATCC
PTA-730, described in WO
01/041558 or US-A 2003-188347); Event RF3 (oilseed rape, pollination control -
herbicide tolerance, deposited
as ATCC PTA-730, described in WO 01/041558 or US-A 2003-188347); Event RT73
(oilseed rape, herbicide
tolerance, not deposited, described in WO 02/036831 or US-A 2008-070260);
event MON-88302-9 (oilseed
rape, herbicide tolerance, ATCC Accession N PTA-10955, WO 2011/153186A1),
event DAS-21606-3
(soybean, herbicide tolerance, ATCC Accession No. PTA-11028, WO
2012/033794A2), event MON-87712-4
Date Recue/Date Received 2021-04-08

CA 02860824 2014-08-28
BCS 14-3033 Ca Prio
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(soybean, quality trait, ATCC Accession N . PTA-10296, WO 2012/051199A2),
event DAS-44406-6 (soybean,
stacked herbicide tolerance, ATCC Accession N . PTA-11336, WO 2012/075426A1),
event DAS-14536-7
(soybean, stacked herbicide tolerance, ATCC Accession N . PTA-11335, WO
2012/075429A1), event SYN-
000H2-5 (soybean, herbicide tolerance, ATCC Accession N . PTA-11226, WO
2012/082548A2), event DP-
061061-7 (oilseed rape, herbicide tolerance, no deposit N available, WO
2012071039A1), event DP-073496-4
(oilseed rape, herbicide tolerance, no deposit N available, US2012131692).
The active ingredients selected from the group consisting of azoxystrobin,
boscalid, cyprodinil, fludioxonil,
iprodione, penthiopyrad, picoxystrobin, prothiocona7ole used according to the
present invention are generally
applied in form of a composition comprising at least one of the active
ingredients as described above. Preferably
the fungicidal composition comprises agriculturally acceptable additives,
solvents, carriers, surfactants, or
extenders.
Suitable organic solvents include all polar and non-polar organic solvents
usually employed for formulation
purposes of such compositions. Preferable the solvents are selected from
ketones, e.g. methyl-isobutyl-ketone and
cyclohexanone, amides, e.g. dimethyl fonnamide and alkanecarboxylic acid
amides, e.g. N,N-dimethyl
decaneamide and N,N-dimethyl octanamide, furthermore cyclic solvents, e.g. N-
methyl-pyrrolidone, N-octyl-
pyrrolidone, N-dodecyl-pyrrolidone, N-octyl-caprolactame, N-dodecyl-
caprolactame and butyrolactone,
furthermore strong polar solvents, e.g. dimethylsulfoxide, and aromatic
hydrocarbons, e.g. xylol, SolvessoTm,
mineral oils, e.g. white spirit, petroleum, alkyl benzenes and spindle oil,
also esters, e.g. propyleneglycol-
monomethylether acetate, adipic acid dibutylester, acetic acid hexylester,
acetic acid heptylester, citric acid tri-n-
btrtylester and phthalic acid di-n-butylester, and also alkohols, e.g. benzyl
alcohol and 1-methoxy-2-propanol.
According to the invention, a carrier is a natural or synthetic, organic or
inorganic substance with which the active
ingredients are mixed or combined for better applicability, in particular for
application to plants or plant parts. The
carrier, which may be solid or liquid, is generally inert and should be
suitable for use in agriculture.
Useful solid or liquid carriers include: for example ammonium salts and
natural rock dusts, such as kaolins, clays,
talc, chalk, quartz, attapulgite, montmorillonite or diatomaceous earth, and
synthetic rock dusts, such as finely
divided silica, alumina and natural or synthetic silicates, resins, waxes,
solid fertilizers, water, alcohols, especially
butanol, organic solvents, mineral and vegetable oils, and derivatives
thereof. Mixtures of such carriers can likewise
be used.
Suitable solid filler and carrier include inorganic particles, e.g.
carbonates, silikates, sulphates and oxides with an
average particle size of between 0.005 and 20 p.m, preferably of between 0.02
to 10 1.trn, for example ammonium
sulphate, ammonium phosphate, urea, calcium carbonate, calcium sulphate,
magnesium sulphate, magnesium oxide,
aluminium oxide, silicium dioxide, so-called fine-particle silica, silica
gels, natural or synthetic silicates, and
alumosilicates and plant products like cereal flour, wood powder/sawdust and
cellulose powder.

CA 02860824 2014-08-28
BCS 14-3033 CA-Prio
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Useful solid carriers for granules include: for example crushed and
fractionated natural rocks such as calcite,
marble, pumice, sepiolite, dolomite, and synthetic granules of inorganic and
organic meals, and also granules of
organic material such as sawdust, coconut shells, mai7P cobs and tobacco
stalks.
Useful liquefied gaseous extenders or carriers are those liquids which are
gaseous at standard temperature and under
standard pressure, for example aerosol propellants such as halohydrocarbons,
and also butane, propane, nitrogen and
carbon dioxide.
In the compositions, it is possible to use tackifiers such as
carboxymethylcellulose, and natural and synthetic
polymers in the form of powders, granules or latices, such as gum arabic,
polyvinyl alcohol and polyvinyl acetate, or
else natural phospholipids, such as cephalins and lecithins, and synthetic
phospholipids. Further additives may be
mineral and vegetable oils.
If the extender used is water, it is also possible to employ, for example,
organic solvents as auxiliary solvents.
Useful liquid solvents are essentially: aromatics such as xylene, toluene or
allcylnaphthalenes, chlorinated aromatics
and chlorinated aliphatic hydrocarbons such as chlorobenzenes, chloroethylenes
or dichloromethane, aliphatic
hydrocarbons such as cyclohexane or paraffins, for example mineral oil
fractions, mineral and vegetable oils,
alcohols such as butanol or glycol and their ethers and esters, ketones such
as acetone, methyl ethyl ketone, methyl
isobutyl ketone or cyclohexanone, strongly polar solvents such as
dimethylformamide and dimethyl sulphoxide, and
also water.
Suitable surfactants (adjuvants, emulsifiers, dispersants, protective
colloids, wetting agent and adhesive) include all
common ionic and non-ionic substances, for example ethoxylated nonylphenols,
polyalkylene glycolether of linear
or branched alcohols, reaction products of alkyl phenols with ethylene oxide
and/or propylene oxide, reaction
products of fatty acid amines with ethylene oxide and/or propylene oxide,
furthermore fattic acid esters, alkyl
sulfonates, alkyl sulphates, alkyl ethersulphates, alkyl etherphosphates,
arylsulphate, ethoxylated arylallcylphenols,
e.g. tristyryl-phenol-ethoxylates, furthermore ethoxylated and propoxylated
arylalkylphenols like sulphated or
phosphated arylalkylphenol-ethoxylates and -ethoxy- and -propoxylates. Further
examples are natural and synthetic,
water soluble polymers, e.g. lignosulphonates, gelatine, gum arabic,
phospholipides, starch, hydrophobic modified
starch and cellulose derivatives, in particular cellulose ester and cellulose
ether, further polyvinyl alcohol, polyvinyl
acetate, polyvinyl pyrrolidone, polyacrylic acid, polymethacrylic acid and co-
polymerisates of (meth)acrylic acid
and (meth)acrylic acid esters, and further co-polymerisates of methacrylic
acid and methacrylic acid esters which
are neutralized with alkalimetal hydroxide and also condensation products of
optionally substituted naphthalene
sulfonic acid salts with formaldehyde. The presence of a surfactant is
necessary if one of the active ingredients
and/or one of the inert carriers is insoluble in water and when application is
effected in water. The proportion of
surfactants is between 5 and 40 per cent by weight of the inventive
composition.

CA 02860824 2014-08-28
BCS 14-3033 Ca Prio
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' ,
It is possible to use dyes such as inorganic pigments, for example iron oxide,
titanium oxide and Prussian Blue, and
organic dyes such as alizarin dyes, azo dyes and metal phthalocyanine dyes,
and trace nutrients such as salts of iron,
manganese, boron, copper, cobalt, molybdenum and zinc.
Antifoams which may be present in the compositions include e.g. silicone
emulsions, longchain alcohols, fatly
acids and their salts as well as fluoroorganic substances and mixtures therof.
Examples of thickeners are polysaccharides, e.g. xanthan gum or veegum,
silicates, e.g. attapulgite, bentonite as
well as fine-particle silica.
If appropriate, it is also possible for other additional components to be
present, for example protective colloids,
binders, adhesives, thickeners, thixotropic substances, penetrants,
stabilizers, sequestrants, complexing agents. In
general, the active ingredients can be combined with any solid or liquid
additive commonly used for formulation
purposes.
The active ingredients or compositions can be used as such or, depending on
their particular physical and/or
chemical properties, in the form of their formulations or the use forms
prepared therefrom, such as aerosols, capsule
suspensions, cold-fogging concentrates, warm-fogging concentrates,
encapsulated granules, fine granules, flowable
concentrates, ready-to-use solutions, dustable powders, emulsifiable
concentrates, oil-in-water emulsions, water-in-
oil emulsions, macrogranules, microgranules, oil-dispersible powders, oil-
miscible flowable concentrates, oil-
miscible liquids, gas (under pressure), gas generating product, foams, pastes,
suspension concentrates,
suspoemulsion concentrates, soluble concentrates, suspensions, wettable
powders, soluble powders, dusts and
granules, water-soluble and water-dispersible granules or tablets, water-
soluble and water-dispersible powders,
wettable powders, natural products and synthetic substances impregnated with
active ingredient, and also
microencapsulations in polymeric substances and in coating materials, and also
ULV cold-fogging and warm-
fogging formulations.
The compositions include not only formulations which are already ready for use
and can be applied with a suitable
apparatus to the plant, but also commercial concentrates which have to be
diluted with water prior to use.
Customary and preferred applications are for example dilution in water and
subsequent spraying of the resulting
spray liquor, application after dilution in oil, direct application without
dilution.
The compositions and formulations generally contain between 0.05 and 99 % by
weight, 0.01 and 98 % by weight,
preferably between 0.1 and 95 % by weight, more preferably between 0.5 and 90
% of active ingredient, most
preferably between 10 and 70 % by weight.
In a preferred embodiment of the present invention the composition comprising
azoxystrobin, boscalid, cyprodinil,
fludioxonil, iprodione, penthiopyrad, picoxystrobin comprises the active
ingredient in an overall amount from 10
g/ha to 800 g/ha, preferably from 100 g/ha to 600 g/ha, more preferably from
130 Win. to 550 g/ha.

CA 02860824 2014-08-28
BCS 14-3033 CA-Prio
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In a preferred embodiment of the present invention the composition comprising
azoxystrobin comprises
azoxystrobin in an overall amount from 50 g/ha to 500 g/ha, preferably from
100 g/ha to 300 g/ha, more preferably
from 150 g/ha to 250 g/ha.
In a preferred embodiment of the present invention the composition comprising
boscalid comprises boscalid in an
overall amount from 100 g/ha to 500 g/ha, preferably from 200 g/ha to 400
g/ha, more preferably from 240 g/ha to
300 g/ha.
In a preferred embodiment of the present invention the composition comprising
cyprodinil comprises cyprodinil in
an overall amount from 10 g/ha to 800 g/ha, preferably from 100 g/ha to 400
g/ha, more preferably from 250 g/ha to
375 g/ha.
In a preferred embodiment of the present invention the composition comprising
cyprodinil comprises fludioxonil in
an overall amount from 75 g/ha to 500 g/ha, preferably from 150 g/ha to 300
g/ha, more preferably from 190 g/ha to
250 g/ha.
In a preferred embodiment of the present invention the composition comprising
fludioxonil comprises fludioxonil
in an overall amount from 75 g/ha to 500 g/ha, preferably from 150 g/ha to 300
g/ha, more preferably from 190 g/ha
.. to 250 g/ha.
In a preferred embodiment of the present invention the composition comprising
fludioxonil comprises cyprodinil in
an overall amount from 10 g/ha to 800 g/ha, preferably from 100 g/ha to 400
g/ha, more preferably from 250 g/ha to
375 g/ha.
In a preferred embodiment of the present invention the composition comprising
iprodione comprises iprodione in
an overall amount from 200 g/ha to 800 g/ha, preferably from 240 g/ha to 600
g/ha, more preferably from 390 g/ha
to 550 g/ha.
In a preferred embodiment of the present invention the composition comprising
penthiopyrad comprises
penthiopyrad in an overall amount from 150 g/ha to 500 g/ha, preferably from
200 g/ha to 400 g/ha, more
preferably from 240 g/ha to 300 g/ha.
In a preferred embodiment of the present invention the composition comprising
picoxystrobin comprises
picoxystrobin in an overall amount from 10 g/ha to 800 g/ha, preferably from
100 g/ha to 500 g/ha, more preferably
from 200 g/ha to 300 g/ha.
In a preferred embodiment of the present invention the composition comprising
prothioconazole comprises
prothioconazole in an overall amount from 50 g/ha to 500 g/ha., preferably
from 100 g/ha to 250 g/ha, more
preferably from 130 g/ha to 180 g/ha.

8 178 1694
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The formulations mentioned can be prepared in a manner known per se, for
example by mixing the active
ingredients with at least one customary extender, solvent or diluent,
adjuvant, emulsifier, dispersant, and/or binder
or fixative, wetting agent, water repellent, if appropriate desiccants and UV
stabilizers and, if appropriate, dyes and
pigments, antifoams, preservatives, inorganic and organic thickeners,
adhesives, gibberellins and also further
processing auxiliaries and also water. Depending on the formulation type to be
prepared further processing steps are
necessary, e.g. wet grinding, dry grinding and granulation.
A further aspect of the present invention is a method of treating Canola
hybrids selected from the group consisting
of 1nVigor L252, L261, 1,160S and L140P plants or plant parts, in particular
L160S plants or plant parts, with a
composition comprising prothioconazole for controlling Sclerotinio
sclerotiorum and/or Sclerotinia minor and/or
increasing yield.
Preferably the composition comprising prothioconazole comprises at least one
further active ingredient selected
from the group consisting of azoxystrobin, boscalid, cyprodinil, fludioxonil,
iprodione, penthiopyrad,
picoxystrobin,
Preferably the composition comprising cyprodinil comprises at least one
further active ingredient selected from the
group consisting of azoxystrobin, boscalid, fludioxonil, iprodione,
penthiopyrad, picoxystrobin,
More preferably the composition comprising cyprodinil also comprises
fludioxonil.
The application of the composition comprising an active ingredient selected
from the group consisting of
azoxystrobin, boscalid, cyprodinil, fludioxonil, iprodione, penthiopyrad,
picoxystrobin, prothioconazole or
mixtures thereof is preferably applied to the Canola hybrids selected from the
group consisting of InVigor L252,
L261, L1605 and L140P plants or plant parts at particular growth stages of the
plant. The term "growth stage"
refers to the growth stages as defined by the BBCH Codes in "Growth stages of
mono- and dicotyledonous plants",
2nd edition 2001, edited by Uwe Meier from the Federal Biological Research
Centre for Agriculture and Forestry.
The BBCH codes are a well-established system for a uniform coding of
phonologically similar growth stages of all
mono- and dicotyledonous plant species.
Some of these BBCH growth stages and BBCH codes for oilseed rape plants are
indicated in the following.
Inflorescence emergence
BBCH 50: Flower buds present, still enclosed by leaves
BBCH 51: Flower buds visible from above ("green bud")
BBCH 52: Flower buds free, level with the youngest leaves
Date Recue/Date Received 2021-06-25

CA 02860824 2014-08-28
BCS 14-3033 CA-Prio
-22-
BBCH 53: Flower buds raised above the youngest leaves
BBCH 55: Individual flower buds (main inflorescence) visible but still closed
BBCH 57: Individual flower buds (secondary inflorescences) visible but still
closed
BBCH 59: First petals visible, flower buds still closed ("yellow bud")
Flowering
BBCH 60: First flowers open
BBCH 61: 10% of flowers on main raceme open, main raceme elongating
BBCH 62: 20% of flowers on main raceme open
BBCH 63: 30% of flowers on main raceme open
BBCH 64: 40% of flowers on main raceme open
BBCH 65: Full flowering: 50% flowers on main raceme open, older petals falling
BBCH 67: Flowering declining: majority of petals fallen
BBCH 69: End of flowering
Preferably in the method of treating Canola hybrid plants or plant parts
selected from the group consisting of
InVigor L252, L261, L1 60S and L140P, preferably L160S plants or plant parts
with a composition according to the
invention, the composition comprising azoxystrobin, boscalid, cyprodinil,
fludioxonil, iprodione, penthiopyrad,
picoxystrobin, prothioconazole is applied to the plants or plant parts at a
growth stage defined by BBCH codes
from BBCH 60 (First flowers open) to BBCH 65 (Full flowering: 50% flowers on
main raceme open, older petals
falling), preferably from BBCH 61(10% of flowers on main raceme open, main
raceme elongating) to BBCH 65
(40% of flowers on main raceme open), more preferably from BBCH 62 (second
leaf unfolded) to BBCH 65 (No
side shoots).
Preferably in the method of treating Canola hybrid plants or plant parts
selected from the group consisting of
InVigor L252, L261, Li 60S and Ll 40P, preferably Ll 60S plants or plant parts
with a composition according to the
invention, the composition comprising azoxystrobin, boscalid, cyprodinil,
fludioxonil, iprodione, penthiopyrad,
picoxystrobin, prothioconazole is applied to the plants or plant parts at a
growth stage wherein 20 to 50 % bloom
stage is present and before development of disease.

CA 02860824 2014-08-28
BCS 14-3033 Ca Prio
-23-
In another embodiment in the method of treating Canola hybrid plants or plant
parts selected from the group
consisting of In Vigor L252, L261, Li 60S and Ll 40P, preferably L 1 60S
plants or plant parts with a composition
according to the invention, the composition comprising azoxystrobin, boscalid,
cyprodinil, fludioxonil, iprodione,
penthiopyrad, picoxystrobin, prothioconazole is applied to the plants or plant
parts a second time five to 15 days
after the first treatment, preferably seven to 12 days and more preferably
seven to 10 days.
In a preferred embodiment of the present invention the composition comprising
an active ingredient selected from
the group of azoxystrobin, boscalid, cyprodinil, fludioxonil, iprodione,
penthiopyrad, picoxystrobin comprises the
respective active ingredient in an overall amount from 0.1 I/ha to 400 I/ha,
preferably from 0.5 I/ha to 300 1/ha,
more preferably from 1 1/ha to 500 1/ha wherein the composition comprises the
respective active ingredient selected
from the group of azoxystrobin, boscalid, cyprodinil, fludioxonil, iprodione,
penthiopyrad, picoxystrobin in an
overall amount from 10 ga to 800 g/1, preferably from 25 g/1 to 600 g/1, more
preferably from 50 g/1 to 500 Wl.
In a preferred embodiment of the present invention the composition comprising
azoxystrobin comprises
azoxystrobin in an overall amount from 0.5 1/ha to 2 1/ha, preferably from 0.7
1/ha to 1.5 1/ha, more preferably from
0.6 I/ha to 1 I/ha, wherein the composition comprises azoxystrobin in an
overall amount from 10 g/I to 800 g/1,
preferably from 50 g/1 to 500 Wl, more preferably from 50 g/1 to 300 WI.
In a preferred embodiment of the present invention the composition comprising
boscalid comprises boscalid in an
overall amount from 100 1/ha to 800 1/ha, preferably from 50 1/ha to 400 1/ha,
more preferably from 20 1/ha to 200
1/ha, wherein the composition comprises boscalid in an overall amount from 15
g/1 to 150 g/1, preferably from 10 g/1
to 100 g/I, more preferably from 7.5 g/1 to 75 WI.
In a preferred embodiment of the present invention the composition comprising
cyprodinil comprises cyprodinil in
an overall amount from 50 I/ha to 400 1/ha, preferably from 25 I/ha to 200
Vha, more preferably from 10 1/ha to 100
1/ha, wherein the composition comprises cyprodinil in an overall amount from 1
g/1 to 100 WI, preferably from 2.5
g/1 to 50 g/1, more preferably from 5 g/1 to 40 WI.
In a preferred embodiment of the present invention the composition comprising
fludioxonil comprises fludioxonil
in an overall amount from 50 I/ha to 400 1/ha, preferably from 25 I/ha to 200
Vha, more preferably from 10 I/ha to
100 1/ha, wherein the composition comprises fludioxonil in an overall amount
from 10 g/1 to 100 g/1, preferably
from 5 g/1 to 50 g/l, more preferably from 1.5 g/1 to 25 Wl.
In a preferred embodiment of the present invention the composition comprising
cyprodinil and fludioxonil
comprises cyprodinil and fludioxonil in an overall amount from 50 1/ha to 400
I/ha, preferably from 25 I/ha to 200
1/ha, more preferably from 10 1/ha to 100 I/ha, wherein the composition
comprises cyprodinil and fludioxonil in an
overall amount from 50 g/1 to 200 g/1, preferably from 10 g/1 to 100 WI, more
preferably from 5 WI to 60 WI.

CA 02860824 2014-08-28
BCS 14-3033 CA-Prio
=
-24-
In a preferred embodiment of the present invention the composition comprising
iprodione comprises iprodione in
an overall amount from 1 Vha to 5 1/ha, preferably from 1.5 1/ha to 5 Vha,
more preferably from 2 1/ha to 3.5 1/ha,
wherein the composition comprises iprodione in an overall amount from 10 g/1
to 800 g/1, preferably from 50 g/1 to
500 g/1, more preferably from 50 g/1 to 300 g/l.
In a preferred embodiment of the present invention the composition comprising
penthiopyrad comprises
penthiopyrad in an overall amount from 0.1 1/ha to 5 1/ha, preferably from 0.5
1/ha to 2 1/ha, more preferably from 1
1/ha to 1.5 I/ha, wherein the composition comprises penthiopyrad in an overall
amount from 50 g/1 to 400
preferably from 100 g/1 to 300 g/1, more preferably from 200 g/1 to 250
In a preferred embodiment of the present invention the composition comprising
picoxystrobin comprises
picoxystrobin in an overall amount from 0.1 Vha to 5 1/ha, preferably from 0.5
1/ha to 2 1/ha, more preferably from
0.8 1/ha to 1.25 1/ha, wherein the composition comprises picoxystrobin in an
overall amount from 75 g/1 to 500
preferably from 150 g/1 to 400 g/1, more preferably from 250 g/1 to 300 g/1.
In a preferred embodiment of the present invention the composition comprising
prothioconazole comprises
prothioconazole in an overall amount from 0.1 1/ha to 0.6 1/ha, preferably
from 0.2 1/ha to 0.5 1/ha, more preferably
from 0.3 1/ha to 0.4 I/ha, wherein the composition comprises prothioconazole
in an overall amount from 200 g/1 to
1000 g/I, preferably from 300 g/I to 750 gil, more preferably from 400 g/I to
500
The inventive treatment of the plants and plant parts with the active
ingredients or compositions is effected directly
or by action on their surroundings, habitat or storage space by the customary
treatment methods, for example by
dipping, spraying, atomizing, irrigating, evaporating, dusting, fogging,
broadcasting, foaming, painting, spreading-
on, watering (drenching) or drip irrigating. It is also possible to deploy the
active ingredients by the ultra-low
volume method or to inject the active ingredient preparation or the active
ingredient itself into the soil.
The invention is illustrated by ¨ but not limited to ¨ the examples below.

CA 02860824 2014-08-28
BCS 14-3033 Ca Prio
-25-
Examples
Example 1 Disease Control
L160S and InVigor 5440 (Bayer CropScience) were planted at four different
locations in Alberta daringMay,
2014. Proline 480 SC (containing 480 g/1 Prothioconazole as a suspension
concentrate ) was applied at the
BBCH stage 62 to 65 at a dosage of 0.15 kg/ha with an application rate of
0.3125 1/ha. The controls were not
treated. 5440 is a commercial available and registered variety.
Disease was assessed one time during the BBCH stages 81 to 85. The average of
the mean of the assessment is
shown.
Sclerotinia disease was assessed using the disease severity index (DSI).
Disease severity index (McRoberts et al.,
Ann. Applied Biology (2003), 142:191-211), was estimated as DSI = 1,(x1n,)/5N
(Cardoso et al., Plant Pathology
(2004), 53: 363-367), in which x, represents disease severity grade based on a
descriptive scale (0: No disease, 1:
Small branch infected, 2: Large branch infected, 3: Stem at least 50% girdled,
4: Plant dead, but some yield
obtained, 5: Plant dead, poor yield) (Bradley et al., Plant Dis. (2006), 90:
215-219), and xi indicating the number
of diseased plants on the i-th grade of the disease scale (Cardoso et al.,
Plant Pathology (2004), 53: 363-367).
Hybrid name DSI DSI Relative
Untreated Treated Disease
Control
[04]
L160 S 20.05 6.85 66%
5440 19.88 8.80 56%

81781694
-26-
Example 2 Yield increase
InVigor Ll 60S and InVigor 5440 (Bayer CropScience) were planted at twelve
different locations showing later
low Sclerotinia disease pressure and at four location later showing high
Sclerotinia disease pressure in Alberta,
Saskatchewan and Manitoba during May, 2014. Proline 480 SC (containing 480 g/l
Prothioconazole as a
suspension concentrate) was applied at the BBCH stage 62 to 65 at a dosage of
0.15 kg/ha with an application
rate of 0.3125 1/ha. The controls were not treated.
Low Sclerotinia Pressure means a level less than a DSI of 10. High Sclerotinia
Pressure means a DS1 level
greater than 10.
Hybrids were harvested between September and October, 2014 using conventional
field scale harvesting
equipment. Yield assessment was completed.
Low Sclerotinia High S clerotinia
Pressure Pressure
,
Hybrid name Relative yield Relative yield
increase compared increase compared
to untreated hybrid to untreated hybrid
No] [%]
L160 S 103 110.5
5440 101.9 107.5
=
Date Recue/Date Received 2021-04-08
_

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Administrative Status

Title Date
Forecasted Issue Date 2022-01-11
(22) Filed 2014-08-28
(41) Open to Public Inspection 2016-02-28
Examination Requested 2019-08-15
(45) Issued 2022-01-11

Abandonment History

There is no abandonment history.

Maintenance Fee

Last Payment of $263.14 was received on 2023-12-07


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Payment History

Fee Type Anniversary Year Due Date Amount Paid Paid Date
Application Fee $400.00 2014-08-28
Maintenance Fee - Application - New Act 2 2016-08-29 $100.00 2016-08-08
Maintenance Fee - Application - New Act 3 2017-08-28 $100.00 2017-08-10
Maintenance Fee - Application - New Act 4 2018-08-28 $100.00 2018-08-10
Maintenance Fee - Application - New Act 5 2019-08-28 $200.00 2019-08-07
Request for Examination $800.00 2019-08-15
Maintenance Fee - Application - New Act 6 2020-08-28 $200.00 2020-08-05
Maintenance Fee - Application - New Act 7 2021-08-30 $204.00 2021-08-04
Final Fee 2022-01-10 $306.00 2021-11-23
Maintenance Fee - Patent - New Act 8 2022-08-29 $203.59 2022-07-20
Maintenance Fee - Patent - New Act 9 2023-08-28 $210.51 2023-07-19
Maintenance Fee - Patent - New Act 10 2024-08-28 $263.14 2023-12-07
Owners on Record

Note: Records showing the ownership history in alphabetical order.

Current Owners on Record
BAYER CROPSCIENCE INC.
Past Owners on Record
None
Past Owners that do not appear in the "Owners on Record" listing will appear in other documentation within the application.
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Description 
Date
(yyyy-mm-dd) 
Number of pages   Size of Image (KB) 
Examiner Requisition 2020-12-08 5 329
Amendment 2021-04-08 14 493
Claims 2021-04-08 1 42
Description 2021-04-08 27 1,261
Examiner Requisition 2021-05-27 5 263
Amendment 2021-06-25 20 801
Description 2021-06-25 27 1,258
Claims 2021-06-25 1 42
Final Fee 2021-11-23 5 149
Cover Page 2021-12-09 1 29
Electronic Grant Certificate 2022-01-11 1 2,527
Abstract 2014-08-28 1 11
Description 2014-08-28 26 1,237
Claims 2014-08-28 2 57
Cover Page 2016-02-08 1 28
Request for Examination 2019-08-15 2 68
Assignment 2014-08-28 4 95
Correspondence 2015-01-15 2 62