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Disponibilité de l'Abrégé et des Revendications

L'apparition de différences dans le texte et l'image des Revendications et de l'Abrégé dépend du moment auquel le document est publié. Les textes des Revendications et de l'Abrégé sont affichés :

  • lorsque la demande peut être examinée par le public;
  • lorsque le brevet est émis (délivrance).
(12) Demande de brevet: (11) CA 2889372
(54) Titre français: ADAPTATEURS POUR DISPOSITIF D'ANALYSE DIRECTE D'ECHANTILLONS ET LEURS PROCEDES D'UTILISATION
(54) Titre anglais: DIRECT SAMPLE ANALYSIS DEVICE ADAPTERS AND METHODS OF USING THEM
(51) Classification internationale des brevets (CIB):
  • H01J 49/04 (2006.01)
  • H01J 49/26 (2006.01)
(72) Inventeurs (Pays):
  • ST. CYR, PAUL L. (Etats-Unis d'Amérique)
  • DELVECCHIO, MICHAEL L. (Etats-Unis d'Amérique)
  • WHITEHOUSE, CRAIG M. (Etats-Unis d'Amérique)
(73) Titulaires (Pays):
  • PERKINELMER HEALTH SCIENCES, INC. (Etats-Unis d'Amérique)
(71) Demandeurs (Pays):
  • PERKINELMER HEALTH SCIENCES, INC. (Etats-Unis d'Amérique)
(74) Agent: MARKS & CLERK
(45) Délivré:
(86) Date de dépôt PCT: 2013-10-27
(87) Date de publication PCT: 2014-05-01
(30) Licence disponible: S.O.
(30) Langue des documents déposés: Anglais

(30) Données de priorité de la demande:
Numéro de la demande Pays Date
13/662,500 Etats-Unis d'Amérique 2012-10-28
13/662,745 Etats-Unis d'Amérique 2012-10-29
13/662,801 Etats-Unis d'Amérique 2012-10-29

Abrégé français

Certains modes de réalisation de l'invention concernent des adaptateurs destinés à être utilisés pour accoupler un dispositif d'analyse directe d'échantillons avec un instrument d'analyse tel qu'un spectromètre de masse par exemple. Dans certains exemples, l'adaptateur peut comprendre un système d'accouplement interne séparé d'un système d'accouplement externe par l'intermédiaire d'un isolant.


Abrégé anglais

Certain embodiments described herein are directed to adapters for use in coupling a direct sample analysis device to an analytical instrument such as, for example, a mass spectrometer. In some examples, the adapter can include an internal coupler separated from an external coupler through an insulator. Certain features, aspects and embodiments are directed to an adapter configured to permit coupling of a direct sample analysis device to an analytical instrument. In some embodiments, the adapter is configured to couple the direct sample analysis device to a mass spectrometer.


Note : Les revendications sont présentées dans la langue officielle dans laquelle elles ont été soumises.

CLAIMS
1. An adapter for installing a direct sample analysis device on a mass
spectrometer, the adapter
comprising:
a capillary sleeve configured to couple to a capillary inlet of the mass
spectrometer;
and
an end cap extension configured to couple to the capillary sleeve, in which
the
capillary sleeve and end cap extension are configured to provide fluidic
coupling between a
sample holder and the mass spectrometer through the capillary inlet.
2. The adapter of claim 1, in which the end cap extension is configured to
couple to a lens
assembly.
3. The adapter of claim 2, in which the lens assembly is configured to
slidingly engage to the
end cap extension.
4. The adapter of claim 1, in which the end cap extension is configured to
slidingly engage to
the capillary sleeve.
5. The adapter of claim 1, in which the capillary sleeve couples to the
capillary inlet through a
friction fit.
6. The adapter of claim 5, in which the end cap extension couples to the
capillary sleeve through
a friction fit.
7. The adapter of claim 1, in which the capillary sleeve comprises an
insulator configured to
electrically decouple the capillary sleeve from the end cap extension.
8. The adapter of claim 7, in which the capillary sleeve is further
configured to center the
capillary inlet.
9. The adapter of claim 1, in which the end cap extension comprises an
insulator configured to
electrically decouple the capillary sleeve from the end cap extension.

22

10. The adapter of claim 9, in which the end cap extension is further
configured to center the
capillary inlet.
11. An adapter for installing a direct sample analysis device on a mass
spectrometer, the adapter
comprising an internal sleeve configured to couple to a capillary inlet of the
mass spectrometer, an
external sleeve coupled to the internal capillary sleeve, and an insulator
between the internal sleeve
and the external sleeve to electrically decouple the internal sleeve from the
external sleeve, in which
the adapter is configured to provide fluidic coupling between a sample holder
and the mass
spectrometer through the capillary inlet.
12. The adapter of claim 11, in which the external sleeve is configured to
couple to a lens
assembly.
13. The adapter of claim 12, in which the lens assembly is configured to
slidingly engage to the
external sleeve.
14. The adapter of claim 11, in which the external sleeve is configured to
slidingly engage to the
internal sleeve.
15. The adapter of claim 11, in which the internal sleeve couples to the
capillary inlet through a
friction fit.
16. The adapter of claim 15, in which the external sleeve couples to the
internal sleeve through a
friction fit.
17. The adapter of claim 11, in which the internal sleeve is sized and
arranged to center the
capillary inlet in the internal sleeve.
18. The adapter of claim 11, in which the insulator comprises at least one
ceramic material.
19. The adapter of claim 11, in which the adapter is configured to permit
coupling of the direct
sample analysis device while maintaining a vacuum of the mass spectrometer.

23

20. The adapter of claim 11, in which the adapter is configured to permit
coupling of the direct
sample analysis device without removing any lenses of the mass spectrometer.
21. An adapter for installing a direct sample analysis device on a mass
spectrometer, the adapter
comprising an internal coupler configured to engage a capillary inlet of the
mass spectrometer, an
external coupler sized and arranged to engage a direct sample analysis lens
assembly, and an
insulator between the internal coupler and the external coupler to
electrically decouple the internal
coupler and the external coupler, in which the adapter is configured to
provide fluidic coupling
between a sample holder and the mass spectrometer through the capillary inlet.
22. The adapter of claim 21, in which the external coupler is configured to
engage the lens
assembly through a friction fit.
23. The adapter of claim 21, in which the internal coupler engages the
capillary inlet through a
friction fit.
24. The adapter of claim 21, in which the internal coupler is sized and
arranged to center the
capillary inlet within the internal coupler.
25. The adapter of claim 21, in which the insulator comprises at least one
ceramic material.
26. The adapter of claim 25, in which the ceramic material is one of
alumina, yttria, titania or
mixtures thereof.
27. The adapter of claim 21, in which each of the external coupler and the
internal coupler
comprises a substantially inert material.
28. The adapter of claim 27, in which the substantially inert material is a
stainless steel.
29. The adapter of claim 21, in which the adapter is configured to permit
coupling of the direct
sample analysis device while maintaining a vacuum of the mass spectrometer.
30. The adapter of claim 21, in which the adapter is configured to permit
coupling of the direct
sample analysis device without removing any lenses of the mass spectrometer.

24

31. An adapter for installing a direct sample analysis device on a mass
spectrometer, the adapter
comprising a coupler sized and arranged to engage to a capillary inlet of the
mass spectrometer, the
coupler comprising an internal surface configured to engage to the capillary
of the capillary inlet and
an external surface electrically isolated from the internal surface through an
insulator, in which the
adapter is configured to provide fluidic coupling between a sample holder and
the mass spectrometer
through the capillary inlet.
32. The adapter of claim 31, in which the external surface of the coupler
is configured to couple
to a lens assembly through a friction fit.
33. The adapter of claim 31, in which the internal surface engages the
capillary inlet through a
friction fit.
34. The adapter of claim 31, in which the internal surface is concentric
and is sized and arranged
to center the capillary inlet within the internal coupler.
35. The adapter of claim 31, in which the insulator comprises at least one
ceramic material.
36. The adapter of claim 35, in which the ceramic material is one of
alumina, yttria, titania or
mixtures thereof.
37. The adapter of claim 31, in which each of the external surface and the
internal surface each
comprise a substantially inert material.
38. The adapter of claim 37, in which the substantially inert material is a
stainless steel.
39. The adapter of claim 31, in which the adapter is configured to permit
coupling of the direct
sample analysis device while maintaining a vacuum of the mass spectrometer.
40. The adapter of claim 31, in which the adapter is configured to permit
coupling of the direct
sample analysis device without removing any lenses of the mass spectrometer.
41. A system for performing direct sample analysis, the system comprising:


a direct sample analysis device; and
an adapter for installing a direct sample analysis device on a mass
spectrometer, the
adapter comprising a capillary sleeve configured to couple to a capillary
inlet of the mass
spectrometer, and an end cap extension configured to couple to the capillary
sleeve, in which
the capillary sleeve and end cap extension are configured to provide fluidic
coupling between
a sample holder and the mass spectrometer through the capillary inlet.
42. The system of claim 41, in which the end cap extension is configured to
couple to a lens
assembly.
43. The system of claim 42, in which the lens assembly is configured to
slidingly engage to the
end cap extension.
44. The system of claim 41, in which the end cap extension is configured to
slidingly engage to
the capillary sleeve.
45. The system of claim 41, in which the capillary sleeve couples to the
capillary inlet through a
friction fit.
46. The system of claim 45, in which the end cap extension couples to the
capillary sleeve
through a friction fit.
47. The system of claim 41, in which the capillary sleeve comprises an
insulator configured to
electrically decouple the capillary sleeve from the end cap extension.
48. The system of claim 47, in which the capillary sleeve is further
configured to center the
capillary inlet.
49. The system of claim 41, in which the end cap extension comprises an
insulator configured to
electrically decouple the capillary sleeve from the end cap extension.
50. The system of claim 49, in which the end cap extension is further
configured to center the
capillary inlet.

26

51. A system for performing direct sample analysis, the system comprising:
a direct sample analysis device; and
an adapter for installing a direct sample analysis device on a mass
spectrometer, the
adapter comprising an internal sleeve configured to couple to a capillary
inlet of the mass
spectrometer, an external sleeve coupled to the internal capillary sleeve, and
an insulator
between the internal sleeve and the external sleeve to electrically decouple
the internal sleeve
from the external sleeve, in which the adapter is configured to provide
fluidic coupling
between a sample holder and the mass spectrometer through the capillary inlet.
52. The system of claim 51, in which the external sleeve is configured to
couple to a lens
assembly.
53. The system of claim 52, in which the lens assembly is configured to
slidingly engage to the
external sleeve.
54. The system of claim 51, in which the external sleeve is configured to
slidingly engage to the
internal sleeve.
55. The system of claim 51, in which the internal sleeve couples to the
capillary inlet through a
friction fit.
56. The system of claim 55, in which the external sleeve couples to the
internal sleeve through a
friction fit.
57. The system of claim 51, in which the internal sleeve is sized and
arranged to center the
capillary inlet in the internal sleeve.
58. The system of claim 51, in which the insulator comprises at least one
ceramic material.
59. The system of claim 51, in which the adapter is configured to permit
coupling of the direct
sample analysis device while maintaining a vacuum of the mass spectrometer.
60. The system of claim 51, in which the adapter is configured to permit
coupling of the direct
sample analysis device without removing any lenses of the mass spectrometer.

27

61. A system for performing direct sample analysis, the system comprising:
a direct sample analysis device; and
an adapter for installing a direct sample analysis device on a mass
spectrometer
without breaking the vacuum of the mass spectrometer, the adapter comprising a
coupler
sized and arranged to engage to a capillary inlet of the mass spectrometer,
the coupler
comprising an internal surface configured to engage to the capillary of the
capillary inlet and
an external surface electrically isolated from the internal surface through an
insulator, in
which the adapter is configured to provide fluidic coupling between a sample
holder and the
mass spectrometer through the capillary inlet.
62. The system of claim 61, in which the external surface of the coupler is
configured to couple
to the lens assembly through a friction fit.
63. The system of claim 61, in which the internal surface engages the
capillary inlet through a
friction fit.
64. The system of claim 61, in which the internal surface is concentric and
is sized and arranged
to center the capillary inlet within the adapter.
65. The system of claim 61, in which the insulator comprises at least one
ceramic material.
66. The system of claim 65, in which the ceramic material is one of
alumina, yttria, titania or
mixtures thereof.
67. The system of claim 61, in which each of the external surface and the
internal surface
comprises a substantially inert material.
68. The system of claim 67, in which the substantially inert material is a
stainless steel.
69. The system of claim 61, in which the adapter is configured to permit
coupling of the direct
sample analysis device while maintaining a vacuum of the mass spectrometer.

28

70. The
system of claim 61, in which the adapter is configured to permit coupling of
the direct
sample analysis device without removing any lenses of the mass spectrometer.

29

71. A method of installing a direct sample analysis device on a mass
spectrometer while
maintaining a vacuum in the mass spectrometer, the method comprising:
coupling a capillary extension to the capillary inlet; and
coupling an end cap extension to the coupled capillary extension, in which the

coupled capillary extension and coupled capillary end cap are configured to
provide fluidic
coupling between a direct sample analysis sample holder and the mass
spectrometer through
the capillary inlet.
72. The method of claim 71, further comprising removing a capillary nozzle
cap prior to coupling
the capillary extension to the capillary inlet.
73. The method of claim 71, further comprising coupling a direct sample
analysis lens assembly
to the coupled end cap extension.
74. The method of claim 71, in which the end cap extension comprises an
insulator configured to
electrically isolate the capillary extension from the end cap extension.
75. The method of claim 71, in which the capillary extension comprises an
insulator configured
to electrically isolate the capillary extension from the end cap extension.
76. A method of installing a direct sample analysis device on a mass
spectrometer while
maintaining a vacuum in the mass spectrometer, the method comprising:
coupling an internal sleeve to a capillary inlet of the mass spectrometer; and
coupling an external sleeve to the coupled internal capillary sleeve, the
external sleeve
comprising an insulator configured to be positioned between the internal
capillary sleeve and
the external sleeve to electrically isolate the internal sleeve from the
external sleeve, in which
the coupled internal and external sleeves are configured to provide fluidic
coupling between a
direct sample analysis sample holder and the mass spectrometer through the
capillary inlet.
77. The method of claim 76, further comprising removing a capillary nozzle
cap prior to coupling
the internal sleeve to the capillary inlet.



78. The method of claim 76, further comprising coupling a lens assembly to
the coupled external
sleeve.
79. The method of claim 76, in which the external sleeve comprises an
insulator configured to
electrically isolate the internal sleeve from the external sleeve.
80. The method of claim 76, in which the internal sleeve comprises an
insulator configured to
electrically isolate the internal sleeve from the external sleeve.
81. A method of installing a direct sample analysis device on a mass
spectrometer comprising a
capillary inlet while maintaining a vacuum in the mass spectrometer, the
method comprising
coupling an adapter comprising a coupler sized and arranged to engage to a
capillary inlet of the
mass spectrometer, the coupler comprising an internal surface configured to
engage to the capillary
of the capillary inlet and an external surface electrically isolated from the
internal surface through an
insulator, in which the adapter is configured to provide fluidic coupling
between a sample holder and
the mass spectrometer through the capillary inlet.
82. The method of claim 81, further comprising removing a capillary nozzle
cap prior to coupling
the internal surface to the capillary inlet.
83. The method of claim 81, further comprising coupling a lens assembly to
the coupled external
surface.
84. The method of claim 83, further comprising initiating sample analysis
of a sample on a direct
sample analysis sample support substantially immediately after coupling the
lens assembly to the
external surface of the adapter.
85. The method of claim 81, further comprising maintaining a substantially
constant vacuum
pressure in the mass spectrometer during the coupling of the adapter.
86. A method of coupling a direct sample analysis device to a mass
spectrometer, the method
comprising coupling an adapter comprising a coupler sized and arranged to
engage to a capillary
inlet of the mass spectrometer to provide fluidic coupling between the
capillary inlet and a direct

31


sample analysis sample support to permit substantially immediate sample
analysis of sample on the
direct sample analysis sample support after coupling of the adapter.
87. The method of claim 86, in which the adapter comprises an internal
sleeve, an external sleeve
and an insulator between the internal sleeve and the external sleeve.
88. The method of claim 86, further comprising maintaining an operating
pressure of the mass
spectrometer during coupling of the coupler to the capillary inlet.
89. The method of claim 86, further comprising coupling a lens assembly to
the coupled adapter
and initiating the sample analysis substantially immediately subsequent to
coupling of the lens
assembly.
90. The method of claim 86, further comprising configuring the adapter to
comprise a separate
internal coupler and a separate external coupler.

32


Une figure unique qui représente un dessin illustrant l’invention.

Pour une meilleure compréhension de l’état de la demande ou brevet qui figure sur cette page, la rubrique Mise en garde , et les descriptions de Brevet , États administratifs , Taxes périodiques et Historique des paiements devraient être consultées.

États admin

Titre Date
(86) Date de dépôt PCT 2013-10-27
(87) Date de publication PCT 2014-05-01
(85) Entrée nationale 2015-04-23

Taxes périodiques

Description Date Montant
Dernier paiement 2017-10-04 100,00 $
Prochain paiement si taxe applicable aux petites entités 2018-10-29 100,00 $
Prochain paiement si taxe générale 2018-10-29 200,00 $

Avis : Si le paiement en totalité n’a pas été reçu au plus tard à la date indiquée, une taxe supplémentaire peut être imposée, soit une des taxes suivantes :

  • taxe de rétablissement prévue à l’article 7 de l’annexe II des Règles sur les brevets ;
  • taxe pour paiement en souffrance prévue à l’article 22.1 de l’annexe II des Règles sur les brevets ; ou
  • surtaxe pour paiement en souffrance prévue aux articles 31 et 32 de l’annexe II des Règles sur les brevets.

Historique des paiements

Type de taxes Anniversaire Échéance Montant payé Date payée
Dépôt 400,00 $ 2015-04-23
Taxe périodique - Demande - nouvelle loi 2 2015-10-27 100,00 $ 2015-04-23
Taxe périodique - Demande - nouvelle loi 3 2016-10-27 100,00 $ 2016-10-04
Taxe périodique - Demande - nouvelle loi 4 2017-10-27 100,00 $ 2017-10-04

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Filtre Télécharger sélection en format PDF (archive Zip)
Description du
Document
Date
(yyyy-mm-dd)
Nombre de pages Taille de l’image (Ko)
Abrégé 2015-04-23 2 81
Revendications 2015-04-23 11 343
Dessins 2015-04-23 12 445
Description 2015-04-23 21 1 297
Dessins représentatifs 2015-05-05 1 16
Page couverture 2015-05-13 1 49
PCT 2015-04-23 16 1 171